My work focused on the consequences of dioxygen (O2) deficit as a limiting factor of exercise in trained and diseased participants.
Despite the importance to characterize the plateau of maximal oxygen uptake (i.e., VO2max) in order to state that the exercise is maximal, the literature reports dissonances in its prevalence i.e., 0 to 90% depending on studies (1–4). The origin of this variability in plateau prevalence is multifactorial. Thus, one part of my work aims to assess the factors limiting maximum performance in the healthy and trained participants.
I am also interested in the functional consequences of an O2 deficit in walking. Indeed, the patient with peripheral arterial dysfunction (Peripheral Arterial Diseased, PAD) may exhibit walking functional discomfort due to exercise induced ischemia (5–7). The evaluation of the Maximum Walking Distance (MWD) represents a crucial issue since a MWD of less than 300 meters is in favor of a revascularization (8). Therefore, the other aim of my work is to test the validity of innovative methodologies based on Global Positioning System (GPS) and Transcutaneous Pressure in Oxygen (TcPO2) during a treadmill test with respect to the assessment of the functional limitation in PAD patients.
- Doherty M, Nobbs L, Noakes TD. Low frequency of the “plateau phenomenon” during maximal exercise in elite British athletes. Eur J Appl Physiol. 2003; 89(6):619–23.
- Gordon D, Hopkins S, King C, Keiller D, Barnes RJ. Incidence of the Plateau at VO2max is Dependent on the Anaerobic Capacity. International Journal of Sports Medicine. 2011 Jan; 32(01):1–6.
- Astorino TA, White AC. Assessment of anaerobic power to verify VO2max attainment. Clinical Physiology and Functional Imaging. 2010 Jul 1; 30(4):294–300.
- Rivera-Brown AM, Frontera WR. Principles of exercise physiology: responses to acute exercise and long-term adaptations to training. PM R. 2012 Nov; 4(11):797–804.
- Resnick HE, Lindsay RS, McDermott MM, Devereux RB, Jones KL, Fabsitz RR, et al. Relationship of high and low ankle brachial index to all-cause and cardiovascular disease mortality: the Strong Heart Study. Circulation. 2004; 109(6):733–9.
- McDermott MM, Liu K, Ferrucci L, Tian L, Guralnik JM, Liao Y, et al. Decline in functional performance predicts later increased mobility loss and mortality in peripheral arterial disease. J Am Coll Cardiol. 2011; 57(8):962–70.
- McDermott MM, Liu K, Ferrucci L, Tian L, Guralnik JM, Liao Y, et al. Greater sedentary hours and slower walking speed outside the home predict faster declines in functioning and adverse calf muscle changes in peripheral arterial disease. J Am Coll Cardiol. 2011; 57(23):2356–64.
- Dormandy JA, Rutherford RB. Management of peripheral arterial disease (PAD). TASC Working Group. TransAtlantic Inter-Society Consensus (TASC). J Vasc Surg. 2000; 31(1 Pt 2):S1–296.